A new look of gastric cancer from epidemiology to clinical management

Gastric cancer (GC) is the third leading cause of malignancyrelated death throughout the world. The mortality rate of gastric cancer is 8.9% after lung cancer (19.7%) and breast cancer (12.9%). The incidence of gastric cancer accounts for the fifth place in malignant tumors [1]. There is a marked geographic variation in the gastric cancer incidence rate. It is highest in East Asia including China and Japan, up to nearly 75%, while one of the lowest rates is in the United States [2] The GC cases in China account for nearly half (47%) of all the gastric cancer new cases throughout the world. The incidence also differs remarkably between genders. In the world, the gastric cancer occurs in man versus woman in a ratio up to 2:1[1].